2

BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL
ABC-DLBCLs have unfavorable outcomes and chronic activation of CBM signal amplification complexes that form due to polymerization of …
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation
During the germinal center (GC) reaction, B cells undergo extensive redistribution of cohesin complex and three-dimensional …
Genome-wide identification of structure-forming repeats as principal sites of fork collapse upon ATR inhibition
  • 500 ATR-dependent sites were identified in the mouse and human genomes

  • ATR-inhibitor-driven fork collapse occurs primarily at structure-forming repeats
  • Repeat structures include non-B form DNA and hairpins (AT-rich and inverted repeats)
  • Discrete repeat types accumulate RPA differentially upon fork collapse