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BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL
ABC-DLBCLs have unfavorable outcomes and chronic activation of CBM signal amplification complexes that form due to polymerization of …
Min Xia, Liron David, Matt Teater, Johana Gutierrez, Xiang Wang, Cem Meydan, Andrew Lytle, Graham W Slack, David W Scott, Ryan D Morin, Ozlem Onder, Kojo SJ Elenitoba-Johnson, Nahuel Zamponi, Leandro Cerchietti, Tianbao Lu, Ulrike Philippar, Lorena Fontan, Hao Wu, Ari M Melnick
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Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation
During the germinal center (GC) reaction, B cells undergo extensive redistribution of cohesin complex and three-dimensional …
Martín A Rivas, Cem Meydan, Christopher R Chin, Matt F Challman, Daleum Kim, Bhavneet Bhinder, Andreas Kloetgen, Aaron D Viny, Matt R Teater, Dylan R McNally, Ashley S Doane, Wendy Beguelin, Maria Teresa Calvo Fernandez, Hao Shen, Xiang Wang, Ross L Levine, Zhengming Chen, Aristotelis Tsirigos, Olivier Elemento, Christopher E Mason, Ari M Melnick
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Genome-wide identification of structure-forming repeats as principal sites of fork collapse upon ATR inhibition

  • 500 ATR-dependent sites were identified in the mouse and human genomes

  • ATR-inhibitor-driven fork collapse occurs primarily at structure-forming repeats
  • Repeat structures include non-B form DNA and hairpins (AT-rich and inverted repeats)
  • Discrete repeat types accumulate RPA differentially upon fork collapse
Nishita Shastri, Yu-Chen Tsai, Suzanne Hile, Deondre Jordan, Barrett Powell, Jessica Chen, Dillon Maloney, Marei Dose, Yancy Lo, Theonie Anastassiadis, Osvaldo Rivera, Taehyong Kim, Sharvin Shah, Piyush Borole, Kanika Asija, Xiang Wang, Kevin D Smith, Darren Finn, Jonathan Schug, Rafael Casellas, Liliya A Yatsunyk, Kristin A Eckert, Eric J Brown
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